Reigning Copa Libertadores champions Atletico Mineiro came from behind to beat 10-man Independiente Santa Fe 2-1 in Group Four on Wednesday.
Atletico started better and had several decent chances, with defender Nicolas Otamendi heading Ronaldinho's free-kick goalwards to bring a top save out of Camilo Vargas.
Santa Fe then lost their main attacker when Wilfred Medina elbowed Otamendi in the face a minute before the break.
Despite that, visiting playmaker Omar Perez fired Independiente ahead with an effort from outside the box in the 59th minute, but two minutes later forward Jo levelled the clash in a one-on-one with Vargas.
With five minutes to go, Neto Berola connected with a superb scissor kick to put Mineiro ahead, meaning they top the group with a perfect record after two games.
Brazilian giants Flamengo overcame Ecuadorians Emelec 3-1 in Group Seven. Fla did not wait long to open the scoring, when former Manchester City star Elano scored with a superb free-kick after 10 minutes.
Hernane doubled the advantage and Everton scored the third after a counter attack. In the closing moments attacker Luis Escalada restored some pride with a long-range strike.
"They played very hard, their defence did not make mistakes, but we had luck and Elano scored. Then, we managed to create some damage with the extra space," commented Hernane.
At Santa Laura, Chileans Union Espanola drew 1-1 with another Brazilian side, Botafogo, in a Group Two encounter.
Cristian Chave fired the hosts ahead in the second half, but, with four minutes to go, striker Juan Carlos Ferreyera headed home a Nicolas Lodeiro long ball to level the clash.
"We gave our best and for several moments we almost clinched the triumph. They took advantage of their only chance. We deserved to win, but a draw is not a bad result," said Botafogo midfielder Jorge Wagner.
In the day's other game, Paraguayan side Cerro Porteno defeated Argentina's Lanus 3-1.