In a year which sees the FIFA Confederations Cup, FIFA U-20 World Cup, FIFA U-17 World Cup and the Final Draw for the FIFA World Cup take place on the Mother Continent; it is fitting that the last match in Ismailia take place between two African teams.
These sides were semi-finalists in the CAF U-20 Championship, with Ghana running out 4-3 winners. But will things be different this time around?
The two African giants know that there is no room for mistakes in knockout football and will be approaching this match as a final in itself. Ghana were given a warning sign in their last match, as Uruguay came back from two goals down to level 2-2, a fate which befell South Africa in their first match. The sides have met before, as recently as the CAF U-20 Championship, earlier this year in the semi-finals. On that day, Ghana ran out 4-3 winners, so expect a high-scoring encounter this time around.
This is the sixth all-African encounter in the history of the FIFA U-20 World Cup. The first two both took place in the 1999 edition, when Mali battled to a 5-4 extra-time win over Cameroon in the Round of 16 before overpowering Nigeria 3-1 in the quarter-finals. Two years later, Ghana overcame Egypt 2-0 in the semi-final. Netherlands 2005 produced another semi-final derby, with Nigeria securing a 3-0 success over Morocco. In 2007 Nigeria once again came out on top against their continental rivals, this time beating Zambia 2-1 in the Round of 16.
"We know South Africa very well, but even so we're going to be studying hard the way they've played in this tournament. We're the favourites, we know that, but we will be taking absolutely nothing for granted. We have to beat them and I want to see us beat them playing beautiful football," Sellas Tetteh, Ghana coach.
"We're delighted to reach the last 16, but Ghana will be very, very tough opponents for us. They are a quality side. It will be a real African derby - and as we know in derbies - anything can happen," Serame Letsoaka, South Africa coach.