The Three Lions return to the FIFA World Cup Stadium, the scene of their opening group fixtures against Korea DPR and New Zealand to face Mohamad Al Jomaa's side, who qualified for the FIFA U-17 World Cup by finishing fourth in Asian qualifying.
But after a draw against Argentina, a last minute loss to Spain and a victory over Honduras, the Syrians are full of confidence and Peacock has warned that they will be no pushovers.
The FA's Head of Coaching insists that the mental approach of his own players will be vital to gaining victory and securing a spot in the quarter-finals.
"What we've done is history and now we have to look forward to the future," he told FIFA.com. "Obviously, the victory over Brazil meant a lot in terms of confidence. It was a very close encounter and it was special after the game, but it will mean absolutely nothing if we don't keep on progressing. There is a long, long way to go and we have to remain totally focused.
"We're now playing cup football now, one-off games, but we're used to it having played in the European finals. We've got three games to get to the final. On the day anything can happen, so we will have to be careful about that. We are full of confidence having won the group, but we won't be complacent.
"Syria will give us another difficult game. We don't know a lot about them, we don't play them very often, but they have come through a very difficult group and I have to give them credit for that. They've shown that they have a lot of qualities and we have to be ready for them."
The England coach is confident that his players will show maturity against a Syrian side, who have been advised by coach Aljomaa to win the game for their country.
Yet just as the gameplan worked against Brazil, Peacock believes that his side can also overcome the west Asians, providing they nullify their technical and physical strengths.
"The players here have got a great capacity to take on board information, to follow instructions," he said. "When you're playing the best teams in the world, you have to raise your game by an extra five or ten per cent of what you have previously been working at, so it sends out a message.
"They react to any given situation. I told them at the beginning of the tournament that we'd be picking teams to win games. Although you always feel sorry for players you leave out, particularly if they have been playing well, we have to make sure that we play to a plan - and I know that we have the right personnel to implement our ideas.
"That's what we'll be doing for the match against Syria. We'll be looking at what they have and we'll be looking at what we can do to combat them."