Goalkeeper Emily Alvarado saved two American attempts as the Mexicans successfully converted each of their four attempts.
The Mexicans took a 1-0 lead in the fifth minute at Catherine Hall Stadium with Briana Woodall heading home, only for Madison Haley to equalise midway through the first half.
Remarkably 2008 FIFA U-17 Women's World Cup runners-up USA have never lost a game in CONCACAF qualifying but have now only progressed to the world stage twice in four attempts. Canada eliminated the Americans from contention at the same stage in 2010, 5-3 on penalties, after a scoreless stalemate.
Marie Metivier, Emily Borgmann (2), Jessie Fleming and Marie Levasseur all netted as Canada maintained their perfect record of reaching all four World Cups since the maiden edition in 2008.