Mauro Boselli scored twice as four time winners Estudiantes de La Plata of Argentina secured a place in the Copa Libertadores final after beating Nacional 2-1 in Uruguay on Wednesday to complete a 3-1 aggregate win.
After a goalless first half, striker Boselli opened the scoring for Alejandro Sabella's Estudiantes seven minutes after the break following a mistake from defender Alejandro Coates.
Alexander Medina volleyed home 20 minutes later to equalise for the home side, but after goalkeeper Mariano Andujar kept Nacional at bay, Boselli rounded off a swift counterattack to seal the win for Estudiantes in injury time.
At the Olimpico Stadium in Porto Alegre on Thursday, Cruzeiro will look to defend a 3-1 first leg lead against fellow Brazilians Gremio to secure their place in the final.
"This squad gave 110 per cent and deserve to be in the final," said Estudiantes coach Sabella. "Now, we have to prepare well for the finals because Gremio or Cruzeiro will surely be tough opponents."