A goal by Fabian Estoyanoff six minutes from the end guided Penarol to the semi-finals of the Copa Libertadores after they claimed a 3-2 aggregate win over Universidad Catolica on Thursday.
The Uruguayans were 2-0 down in Chile with the game heading for a penalty shoot-out before the former Valencia forward converted a cross by Luis Aguiar in the 84th minute to send his side into their first semi-final for 23 years where they will face Velez Sarsfield of Argentina.
Fernando Meneses and Roberto Gutierrez had put Catolica ahead but goalkeeper Paulo Garces failed to catch Aguiar's cross and the visitors progressed.
Penarol coach Diego Aguirre said: "We played looking for one goal since the first minute. But we couldn't find it until the end. We created several chances, but we couldn't score and we suffered a lot. Luckily there was justice at the end.
"As a Penarol fan, I'm happy for living this, putting the team in a Copa Libertadores definition again. There are left only the best four teams in the continent and Penarol is one of them. We have to be proud of that."
In Paraguay, Cerro Porteno secured a 1-0 victory on the night, 2-1 on aggregate, over Jaguares of Mexico, Pedro Benitez hitting the winner with 20 minutes left. Cerro Porteno will now play Brazil's Santos in the other semi-final.