Cerro Porteno have taken sole control of Group Five in the Copa Libertadores with a 2-0 win over Deportivo Tachira in Venezuela. Argentinian striker Roberto Nanni put the Paraguayan giants in front after 20 minutes before Ivan Torres doubled their advantage after the break.
The win gives them a two-point cushion over Colo Colo, who went down 3-2 to Santos in Brazil. The hosts made hard work of it, however, having two men sent off and allowing the Chileans to recover from 3-0 down.
Santos were cruising after goals from Elano, Danilo and Neymar, but the tide quickly began to turn as Neymar earned a second yellow card for celebrating his strike using a mask in the 52nd minute. Santos forward Ze Eduardo and Colo Colo captain Andres Scotti were then both shown red for a scrap four minutes later.
Patricio Jerez cut the gap in the 82nd minute and - after the substituted Elano was banished from the bench for his protests - Diego Rubio made it 3-2 with three minutes to go. However, Colo Colo would also finish with nine men as Cristobal Jorquera was shown a late red card.
In Mexico, Jaguares edged out reigning champions Internacional 1-0 as Antonio Salazar turned in Jorge Rodriguez's cross. It is the first defeat of this season's competition for Internacional, but they remain top of Group Six, one point clear of Jaguares.
Venezuela's Caracas continue to surprise in Group Four, beating Union Espanola 2-1 in Chile. They had to come from behind, however, as Sebastian Jaime headed in for the hosts after just three minutes before goals from Angelo Pena and Josef Martinez, the second eight minutes from time, turned it around to send Caracas two points clear in the group. Chile's Universidad Catolica, who are two points behind, play Velez Sarsfield tomorrow.
America are top of Group Three after coming from behind to beat Argentinos Junior 2-1. Franco Niell headed Argentinos in front three minutes into the second half, but Vicente Matias Vuoso levelled with 18 minutes to go before Daniel Marquez won it with a header six minutes from time.
A brace from Santiago Garcia saw Uruguay's Nacional beat Fluminense 2-0 in Montevideo, despite the second-half dismissal of Marcelo Gallardo.
"In the first half, we made a number of mistakes, but then we managed to handle the game," Garcia said. "This is what we should have done since the Libertadores started. We started in very poor form but we are getting over it."
America lead the group with nine points, two more than Argentinos Juniors and Nacional, while Fluminense remain bottom with five.