Godoy Cruz came from behind to inflict a 3-1 defeat on Argentinian rivals Independiente in the Copa Libertadores on Thursday.
Facundo Parra gave Independiente a 16th-minute lead but Hernan Fredes' own goal levelled the scores in the 28th and four minutes later Ariel Rojas gave Godoy the lead. Ruben Ramirez got a third goal 11 minutes into the second half as Godoy joined Penarol at the top of Group 8 on six points, three more than Independiente.
Chile's Union Espanola claimed a key win in Group 4, 2-1 over Argentina's Velez Sarsfield. The hosts took a fourth-minute lead through Martin Liguera and in the 26th Braulio Leal doubled the advantage, before David Ramirez replied midway through the second half.
Union Espanola coach Jose Luis Sierra said: "We're satisfied because the team had a good performance, mainly with ball control. We were also a tough team in defence - that gives us hope both in the national and the international futures."
The group is very tight - after three rounds Venezuela's Caracas lead with six points, while Union and their Chilean rivals Universidad Catolica have four, one more than Velez.
In Group 5, Paraguay's Cerro Porteno could only manage a 1-1 draw at home to Venezuela's Deportivo Tachira. Roberto Nanni opened the scoring for the hosts in the first half, with Sergio Herrera equalising on the hour.