Libertad crushed Peruvian champions Universidad San Martin 5-1 in Paraguay to take over at the top of Copa Libertadores Group 1.
The Paraguayan side, coached by Gregorio Perez, hit back from a goal down to assume control at the top of the group with seven points, one more than the Peruvian team.
Argentinian forward German Alemanno put the visitors ahead in the fourth minute by heading in Aldo Corzo's cross, but Rodrigo Rojas equalised ten minutes later with a right-foot shot from Victor Ayala's cross. Angel Orue gave Libertad the lead five minutes later, before Manuel Maciel made it 3-1 in the 27th minute. Ayala headed in Carlos Bonnet's cross five minutes into the second half, before Omar Pouso rounded off the scoring - also with his head - five minutes from time.
Ayala said afterwards: "We played a great match. Our form was poor in the beginning, but we calmed down and scored a lot of goals. We did a good job tonight. We were calm enough to get over (conceding) that goal."
In Mexico, Jaguares recorded their second win in Group 6 as they defeated Emelec 2-1. Francisco Torres opened the scoring with a penalty two minutes before half-time, then Antonio Salazar doubled the advantage midway through the second half.
Cristian Menendez reduced the deficit two minutes later but the Ecuador side could not find an equaliser and they are now two points behind Jaguares - who have picked up six points from their three games.