A 5-1 triumph over AJSM from the Comoros islands took Young Africans through to the second round in a tie reduced to one leg because their opponents do not have an international-standard ground.
Kenyan international Bernard Mwalala was the hero of the Dar es Salaam club, scoring twice in the second half to seal success after goals from Abdi Kassim, Gaudance Mwaikimba and Said Maulid put Yanga in control.
It was also a dream debut for Serb coach Milutin Sredojevic, fired by South African club Orlando Pirates this month after guiding them to the 2006 African Champions League semi-finals.
Esperance, back after a one-year absence from a competition they won in 1994, wasted no time getting the better of Renaissance in Tunis with three goals inside 20 minutes setting up a 4-0 victory.
Aymen Letaif was the hat-trick hero, scoring after 14, 20 and 47 minutes for the legendary 'Blood and Gold' after Moyen Chaabani had put the local club ahead within six minutes of the kick-off.
Algerian challengers USMA and Jeunesse Sportive Kabylie were other clubs to take advantage of playing at home, winning by 3-1 margins against AS FNIS of Niger and FC Balantas of Guinea Bissau respectively.
Kabylie, who have won the Champions League twice, the Cup Winners Cup once and the CAF Cup three times, also built a three-goal lead before conceding a goal late in the second half.
Nassim Oussalah struck after 10 minutes for the 'Canaries', who stage African ties in Algiers despite being based in the eastern town of Tizi-Ouzou, and Youcef Saibi scored either side of half-time before Vani Martins replied.
Newcomers Nasawara United of Nigeria will be satisfied with a 1-1 draw at ASFA Yennenga of Burkina Faso. Nassirou Aliou put the visitors ahead and Ismael Alassane levelled with a late second-half penalty.
A controversial goal six minutes into the second half by Carlos Lopes earned Petro Atletico of Angola a 1-0 victory over Namibian visitors Civics in Luanda.
Civics, who last year earned a shock first round win over Esperanca Sagrada of Angola, claimed the ball entered the net via the side netting.