Whether you base your predictions on faith or cold hard calculations, this weekend presents some very tough choices for predictors.
The men from White Hart Lane may be lingering near the relegation zone and suffer from erratic bouts of form, but the fact remains: Spurs are unbeaten by Chelsea, Liverpool and Arsenal in their most recent encounters against the Premier League's top teams.
Can Spurs carry on this run? A Spurs win or draw at home against Manchester United will net backers over 80 points.
In France, the Stade Velodrome is the magnificent setting for what promises to be an epic encounter. Second place Marseille will relish the opportunity to catch league leaders Lyon, who are suffering from a dangerous dip in form.
A Marseille win will lock the two teams on equal points at the top of the Ligue 1, while a loss will strengthen Les Gones chances of an eighth successive league title. With 85 points in the bag for a Marseille win, how many brave predictors will fight the odds?
In Argentina, the last match of the season could decide the Primera A champion. Undefeated in six matches, 11th-placed Argentinos Juniors will host San Lorenzo who are locked at the top of the table in a three way stand-off. Can the underdogs upset both the Primera A and predictor league standings?
In the Serie A, Juventus host AC Milan. Both teams sit locked on 30-points under league leaders, Inter Milan. The three points up for grabs in this Italian derby could split the top two teams from the rest of the pack.
Match of the week
In La Liga, archrivals Barcelona and Real Madrid prepare for Spain's fiercest derby - El Clasico.
New coach Juande Ramos is charged with a monumental task in his first week at the helm - beating Barcelona at the Camp Nou with a demoralized and injury-riddled Madrid team.
A miraculous Los Merengues win could earn faithful backers over 80 points, but how many predictors are willing to take such a leap of faith?