FIFA.com brings you its customary review of the weekend's most exciting club action, including the start of new campaigns in Mexico and Paraguay, and the fiercely contested battles for top spot in Brazil, Korea Republic and the USA.
Brasileirao: Palmeiras take clássico honours
Bragging rights in the Paulista derby went to Palmeiras, who beat rivals Corinthians 3-0 thanks to an Obina hat-trick. The win also took O Verdão level on points with leaders Atletico Mineiro.
Goias, for their part, are proving a real handful for this year's title hopefuls. Having already beaten Palmeiras, they beat the pacesetters 1-0 away to hand their hosts only their second defeat so far.
Big game: Reigning champions Sao Paulo will be breathing a little easier after a 2-1 win at Barueri, O Tricolor Paulista's first away win this season.
Headline grabber: Ronaldo fans will be on tenterhooks after the Corinthians forward was taken off against Palmeiras.
Mexican Apertura: Promising start
Expectations were high across the board as the Apertura got underway, with Toluca and Guadalajara playing their part with a thrilling seven-goal encounter. Toluca edged the match 4-3 thanks to an injury-time winner from Israel Lopez.
Clausura 2009 champions Pumas, meanwhile, suffered an early setback when going down 1-0 to an Atlas side with former Mexico coach Ricardo La Volpe at its reins.
Big game: Tecos and Pachuca kicked off the Apertura in style on Friday in a pulsating 3-2 win for the visiting Tuzos, for whom Argentina's Christian Gimenez scored the winner from the penalty spot.
Headline grabber: Jaguares helped themselves to all three points away to struggling Cruz Azul, who, after last season's poor showing, need a swift improvement to avoid a relegation battle.
American Major League Soccer: Tighter at the top
Western Conference hopefuls Seattle Sounders and Los Angeles Galaxy could only draw 0-0 and 1-1 against Chicago Fire and Kansas City Wizards respectively. This proved a let-off for leaders Houston Dynamo, who remain three points clear of the Sounders and four ahead of Galaxy despite a 1-0 loss at home to New England Revolution.
Big game: Reigning MLS champions Columbus Crew increased their unbeaten home run to 19 games and moved top of the Eastern Conference with a 3-2 win over Toronto.
Headline grabber: Fans of Real Salt Lake and Colorado Rapids had most goals to celebrate this weekend when their teams stormed to 4-2 and 4-0 victories over FC Dallas and New York Red Bulls respectively.
Japanese J.League: Kashima held again
Despite being held 1-1 by Kashiwa Reysol, leaders Kashima Antlers extended their advantage at the top to ten points after chasers Urawa Red Diamonds lost their second game in a row. The Urawa outfit went down 3-0 at home to Nagoya Grampus, for whom Keiji Tamada fired a double.
Big game: This season's surprise package Albirex Niigata edged past Urawa into second spot on goal difference after picking up a 1-1 draw against Montedio Yamagata.
Headline grabber: Marquinhos's leveller for Kashima ensured the division's top team extended their unbeaten run to 17 games.
Jeonbuk Motors had to make do with a 1-1 draw against Ulsan Horang-i, though the result took them level to within just one point of current Korea Republic K-League leaders FC Seoul.
Over in the Russian Premier League, Spartak Moscow's 2-1 derby win at local rivals CSKA Moscow means they are now just one point behind leaders Rubin Kazan, who drew 0-0 at Zenit St Petersburg.
An Esteban Paredes hat-trick for Colo Colo in a 3-1 win over Universidad de Concepcion fired his team to the top of the Chilean Clausura, level on points with Audax Italiano, who drew 2-2 against Palestino.
Finally to the Paraguayan Clausura and there was a surprise result on the opening day of the new campaign, with Apertura champions Cerro Porteno going down 2-0 to Nacional.