Leadership could change hands in Brazil, Mexico, the USA, China PR, Korea Republic and Thailand this weekend, while the top two will collide in Singapore. FIFA.com anticipates the action.
Brasileirao: Palmeiras out to consolidate
The form of goalkeeper Marcos and especially playmaker Diego Souza has propelled Palmeiras to the summit, and they must defend this position at relegation-placed Sport. Runners-up Atletico Mineiro, spearheaded by a resurgent Diego Tardelli, will host struggling Coritiba, while Goias, in fourth, visit Santo Andre.
Sao Paulo have risen to 11th under new coach Ricardo Gomes, and will try to maintain their progress at fifth-placed Vitoria. Cruzeiro, for their part, will strive to continue marching towards the top half when they travel to tenth-placed Gremio for a repeat of their recent Copa Libertadores semi-final.
High stakes: Atletico Paranaense and Fluminense, both in the relegation zone, will collide in Curitiba.
Players to watch: Seventh-placed Flamengo's Adriano and Gilmar of tailenders Nautico are two of the leading scorers in the competition. Who will win their shootout at the Maracana?
Mexico Apertura: Quartet eye six from two
At least one of four 100 per cent starts will be extinguished when Jaguares entertain another of Round 1's victors, Toluca. Atlas will hope Edgar Pacheco can shoot them on to six points at Monterrey, whose goalkeeper Jonathan Orozco earned a clean sheet in victory in this fixture on his professional debut in 2005.
Pachuca, for whom Christian Gimenez hit the winner first time out, will welcome Queretaro to Hidalgo.
High stakes: Reigning Clausura kings Pumas and national giants Cruz Azul will compete looking to put their first points on the board.
Players to watch: The duel between Guadalajara forward Javier Balcazar and Tigres defender Fernando Ortiz could dictate the outcome of their meeting.
American Major League Soccer: DCU to test Dynamo
Fresh from scoring for the MLS All-Stars in midweek, exciting winger Brad Davis will strive to consolidate Houston Dynamo's place atop of the Western Conference at home to DC United, third in the opposite section and with Christian Gomez thriving.
Seattle Sounders, three points adrift of the Dynamo, will visit section tailenders San Jose Earthquakes, while Eastern Conference runners-up Chicago Fire will task Cuauhtemoc Blanco with undoing the Yura Movsisyan-led Real Salt Lake.
High stakes: New England Revolution and Toronto FC, fifth and fourth in the east respectively, will square off.
Players to watch: Colorado Rapids will need Jacob Peterson at his best when Eastern Conference pacesetters Columbus Crew, for whom Jason Garey has hit three goals in two games, pay them a visit.
Korean K-League: Leaders head into Jijidae derby
With Dejan Damjanovic firing on all cylinders, FC Seoul have taken 19 points from a possible 21 to race into pole position. The capital side face a strict examination at the home of arch-rivals Suwon Bluewings in Round 17, despite the fact the reigning champions are languishing 12th in the 15-team division.
Runners-up Jeonbuk Motors will charge the competition's leading marksman Lee Dong-Gook with shooting them to victory at Seongnam Chunma, while Choi Sung-Kuk will carry third-placed Gwangju Sangmu's hopes against visiting Busan I'Park.
High stakes: Daegu and Daejeon Citizen, bottom and third-bottom respectively, will meet desperate to ease their relegation fears.
Players to watch: Pohang Steelers, five points off the pace in fourth, will hope Cho Chan-Ho's finds his rhythm when they visit tenth-placed Ulsan Horang-I team that has Lee Jin-Ho in form.
Just two points divide the top three in the Chinese Super League, and they will all hit the road as the second half of the campaign begins. Leaders Beijing Guo'an, second-placed Henan Jianye and Shandong Luneng will face respective strugglers Chongqing Lifan, Guangzhou Yiyao and Shenzhen.
The front two in the race for the Sinaporean S-League will do battle. With home advantage and Noh Alam Shah thriving, Tampines Rovers will have the chance to cut Singapore Armed Forces' lead to a mere two points. However, they will be wary of striker Aleksandar Duric, who condemned them to defeat in their first meeting this term.
Thai Premier League frontrunners Chonburi will travel to Osotspa, four points behind them in fourth, while runners-up Bangkok Glass will host rock-bottom Chula United.