A weekend awash with big derbies and top-of-the-table duels is at hand. FIFA.com looks ahead to the action in Argentina, Brazil, Costa Rica, Fiji, South Africa, Thailand and the USA.
Argentinian Apertura: Top four demand victory
Forwards Gonzalo Bergessio and Andres Silvera will be charged with taking San Lorenzo on to 19 points from a possible 21 and keeping them top against mid-table Arsenal. If the visitors can pocket their first away points of the campaign, third-placed Tigre and their in-form No10 Martin Morel will expect to capitalise at home against lowly Gimnasia Jujuy.
Runners-up Boca Juniors and fourth-placed Velez Sarsfield, level on points, will also reckon on victory. The latter will face struggling Banfield away, while Los Xeneizes will visit newly-promoted Godoy Cruz.
Players to watch: Out-of-sorts Rosario Central will be hoping for some inspiration from veteran Kily Gonzalez, but Daniel Vega will be out to continue his and San Martin's impressive start to the season at the Estadio Gigante de Arroyito.
Big game: Estudiantes' rivalry with Gimnasia is intense, and so is Los Pincharratas' need for points in the La Plata derby, having taken just five in seven outings to date.
Brasileirao: Leaders under pressure
Gremio's enduring stay atop of the standings will come under intense scrutiny on Sunday. Then, O Tricolor Gaúcho will seek their first win in four attempts at arch-rivals Internacional, whose recent form has owed much to the brilliance of Alex and Nilmar. Palmeiras, one point back in second, will expect Diego Souza, Kleber and Alex Mineiro to see off Nautico in Recife, and fourth-placed Flamengo will reckon on victory at home to Sport.
Sao Paulo and Cruzeiro, fifth and third respectively, will square off at the Morumbi, where Brazil midfielder Hernanes and Raposa revelation Guilherme will endeavour to shine.
Big game: Sixth-placed Botafogo require a home win to preserve their title challenge, while second-bottom Fluminense need victory in the Grandfather Derby to ease their relegation fears.
Players to watch: The confrontation between Coritiba striker Keirrison and Atletico Paranense defender Rhodolfo could be central to the outcome of their derby.
American Major League Soccer: Quakes' quest resumes
A nine-game unbeaten streak has catapulted San Jose Earthquakes to within four points of an automatic play-off slot. Frank Yallop's side will hope goalkeeper Joe Cannon and the pacy Darren Huckerby can keep this run going at home to Real Salt Lake, who could go second in the Western Conference with victory.
This position currently belongs to Chivas USA, who will task the likes of Atiba Harris, Sacha Kljestan and Ante Razov with undoing Kansas City Wizards, occupiers of the final play-off qualification berth.
Big game: Two points from a possible 12 has left DC United clinging on to a play-off spot, while their hosts FC Dallas are just outside the qualification places.
Players to watch: New England Revolution's Taylor Twellman and Alejandro Moreno of Columbus Crew have the ability to decide their top-of-the-table duel in the Eastern Conference.
Thai Premier League: Hope consumes Chonburi
PEA have control of their own destiny as their unexpected title charge enters its finishing straight. With three rounds remaining, the Electric Men lead Chonburi by a point and will be expected to beat mid-table opposition in their last two matches. That is why so much emphasis has been placed on their trip to third-placed BEC Tero Sasana, to whom they lost 3-1 at home earlier this season.
Chonburi will have one eye on that game, but the defending champions, spearheaded by Ivorian ace Kone Mohamed, must avoid complacency against a Port Authority side fighting against the drop.
Big game: Royal Thai Army simply must beat high-flying TOT away to have any chance of survival.
Players to watch: Arian Jean Akassou appears the biggest threat to the near-six-month unbeaten league record of PEA, whose 20-year-old goal-getter Ronnachai Rangsiyo will be out to underline why he is one of the hottest prospects in Asia.
South African Premier Soccer League: Maritzburg next for Mulenga
Seven points from three games has Bidvest Wits at the summit, and although three clean sheets from Energy Murambadoro and two goals from Phikolethu Spelman have aided their cause, the Clever Boys' position is most indebted to Clifford Mulenga. Next in the Zambian sensation's sights are Maritzburg United, who have taken four points from their opening two contests.
Runners-up Supersport United and Mamelodi Sundowns will put their 100 per cent records against one another, while third-placed Thanda Royal Zulu will visit AmaZulu.
Big game: Bay United will be desperate to win their maiden home match in the PSL, but the country's oldest club Orlando Pirates will be out to upset the party.
Players to watch: Reneilwe Letsholoyane is in high spirits after scoring the winning penalty for Kaizer Chiefs in the MTN8 Cup final on Tuesday. Can he win his midfield battle with Ajax Cape Town's emerging star Granwald Scott?
The biggest game on the Costa Rican calendar will unfold in San Jose on Saturday, when fierce enemies and the country's two most successful clubs do battle. Saprissa, second in Group A, will entrust Alejandro Alpizar with sinking his former employers, while the on-song Ariel Rodriguez will strive to help Alajuelense consolidate their leadership of Group B.
Domestic giants and bitter rivals will also collide in Fiji this weekend, when the title race will reach an enchanting climax. Labasa and Ba will enter the final match of the Super Six Series level on points, with the latter needing only a draw on their travels courtesy of their superior goal difference. Can young goalkeeper Epeli Codro and defensive rock Malakai Kenahewe help the Men in Black achieve this, or will the flair of Amani Makoi and Roy Krishna prove decisive for the defending champions?
Internacional-Gremio, Saprissa-Alajuelense and Columbus Crew-New England Revolution are among the matches on the FIFA World Leagues Predictor's Round 6 menu. If you haven't already, be sure to sign up and take a shot at winning this weekend's prize.