After the two-week international break, it is back to domestic action this weekend. Highlights include Roma-Inter Milan in Italy, Hamburg-Schalke in Germany and Hull City-West Ham United in England, while there are derbies in Madrid between Atletico and Real and in the west of France between Bordeaux and Toulouse. FIFA.com is on hand to preview the pick of the weekend's action.
Premier League: Victories the target for big four
While Chelsea will not take anything for granted when they journey up to Middlesbrough, Liverpool, Arsenal and Manchester United - at home to Wigan Athletic, Everton and West Bromwich Albion respectively - will be expecting wins.
Elsewhere, newly promoted Hull City, currently riding high in third place, take on West Ham United and their new manager Gianfranco Zola.
The question: Which of this season's two surprise packages - Hull City or West Ham United - will continue to keep pace with the leaders?
The big match: Hull City-West Ham United, Sunday 4:00 pm, KC Stadium.
The quote: "It's strange to think that I'm the veteran of the midfield. We're finding it hard to win matches because we don't have the necessary experience," Cesc Fabregas, Arsenal midfielder
Ligue 1: Nerves creeping in at Bordeaux
If they are to stay in the hunt at the top of the table, Bordeaux will need to take all three points from their derby against a Toulouse team who have won four in a row and are unbeaten in seven in the league.
Lyon, who lost their last match 3-0 to Rennes, will be looking to get back to winning ways against Lille, while the other big-city clubs Marseille, away to Valenciennes, and Paris Saint-Germain, at home to Lorient, are also in need of success.
The question: Will second-placed Toulouse be able to continue their strong start to the season by bringing at least a point back from their trip to last year's runners-up Bordeaux?
The big match: Bordeaux-Toulouse, Saturday 7:00 pm, Stade Jacques Chaban-Delmas.
The quote: "I think it will be a tough match for Lille. A lot of the players know me, and it'll be the game of the season for many of them. I know how they like to play," Claude Puel, Lyon coach
La Liga: The Madrid derby
Atletico Madrid are having a tough time of it this month. After going down 6-1 to Barcelona at the Camp Nou, Javier Aguirre's men now have to face their city rivals Real Madrid, who have made a good start to the season, winning four and drawing one of their six matches so far.
Elsewhere, Villarreal and Valencia will be looking to continue their strong starts to the season against Espanyol and Numancia respectively. Barcelona, meanwhile, travel to Athletic Bilbao, a team once dominant in their own stadium but who have lost two out of three at home so far this season.
The question: After their defeat by Barcelona, will Atletico be able to bounce back in time for the Madrid derby?
The big match: Atletico Madrid-Real Madrid, Saturday 8:00 pm, Estadio Vicente Calderon.
The quote: "Atletico-Real Madrid is a derby like no other. Fans at the Vicente Calderon pile the pressure on opposing teams. It won't be easy for us but it will give us some extra motivation," Ruben de la Red, Real Madrid midfielder
Serie A: Roma under pressure
The weekend's big match in Italy is Roma's battle with Inter Milan. In recent seasons, this has tended to be the match-up between first and second in the league, but Roma find themselves struggling this time around and will be looking to bounce back by taking three points off the Nerazzuri.
Juventus will have to be at their best when they travel to sixth-placed Napoli, while AC Milan are at home to Sampdoria. Fiorentina, for their part, welcome struggling Reggina and leaders Lazio travel to Bologna, who are also in the relegation zone.
The question: After a distinctly average start to the season, will Roma be able to defeat Inter Milan and erase the memory of last year's 4-1 home defeat to the eventual league champions?
The big match: Roma-Inter Milan, Sunday 8:30 pm, Stadio Olimpico.
The quote: "If Yoann (Gourcuff) can carry on playing like that all season, we'll gladly have him back," Carlo Ancelotti, AC Milan coach
Bundesliga: Hamburg on a roll
Hamburg-Schalke is the weekend's big match in Germany. The league title is currently wide open, with five points separating the top eight and a mere three between second and tenth. Beating your immediate rivals is thus top priority, which is why Hamburg will be hoping to make home advantage count against Schalke and extend the gap over them to seven points.
Bayern Munich badly need to rediscover their form away to Karlsruhe if they are to avoid dropping further into the lower reaches of the table, while Hoffenheim, Stuttgart and Bayer Leverkusen - second, third and fourth respectively - are all away from home, travelling to Hanover, Hertha Berlin and Eintracht Frankfurt respectively.
The question: Can Hamburg win at home and put some daylight between themselves and the five teams in the chasing pack, who are all away?
The big match: Hamburg-Schalke, Sunday 5:00 pm, HSH Nordbank Arena
The quote: "Jurgen needs to handle the criticism from the media and the public, but at the same time, those in charge of the club should keep a cool head, Franz Beckenbauer, Bayern Munich president
In the Netherlands, it is second versus third with PSV Eindhoven away to immeadiate pursuers NAC Breda. A win will see the former go top of the league if Ajax manage to avoid defeat against leaders Groningen.
In Portugal meanwhile, early pacesetters Porto are at home to surprise package Leixoes, currently in third. Elsewhere, Benfica take on Naval while Sporting face Pacos de Ferreira away.
Finally, Galatasaray will be at home to leaders Trabzonspor in Turkey on Sunday, in what promises to be a gripping contest, while Besiktas and Fenerbahce travel to Genclerbirligi and Kocaelispor respectively.