After a week of international action the spotlight returns to the domestic scene with the Serie A summit meeting between Inter Milan and Juventus topping the bill. FIFA.com looks ahead to that game and much more besides in its weekly European league preview.
Serie A: Battle rejoined in Milan
One match guaranteed to set pulses racing in the land of calcio is the classic Inter-Juventus derby, especially when both sides are battling it out at the top of the table. The old foes cross swords again this weekend with the Turin giants out to extend their five-game winning run and erase the three-point gap separating them from leaders Inter.
Keeping a very close on eye on events at the San Siro will be second-placed AC Milan, who lie a point behind the Nerazzurri and, as fate would have it, take on Juve's city neighbours Torino. Meanwhile, Roma will set out to maintain their mini-revival when they travel to Lecce.
The question: Having scored five goals in Genoa's last three games, can Diego Milito keep his hot streak going against Lazio?
The big game: Inter Milan-Juventus, Saturday 20.30 CET, Stadio Giuseppe Meazza
The quote: "The table doesn't reflect how good Roma are. We're really going to have to be on our guard because they're bound to be full of confidence after winning the Rome derby." Fabiano, Lecce defender
Premier League: Will the real Arsenal please stand up?
Capable of overpowering Manchester United one day and falling flat against Aston Villa the next, the Gunners have delighted and infuriated their fans in equal measure so far this season. Already nine points adrift of leaders Chelsea and weakened by the loss of Theo Walcott to injury, the Londoners' need to find some consistency quickly, starting with Saturday's trip to Manchester City.
Third-placed Manchester United visit in-form Aston Villa and will need to be at their very best if they are stay in touch with Liverpool, who entertain Fulham, and Chelsea, who host Newcastle United.
The question: Chelsea have won four on the trot without conceding a goal. Can they maintain their impressive form against the Magpies on Saturday?
The big game: Aston Villa-Manchester United, Saturday 18.30 CET, Villa Park
The quote: "It feels like only yesterday when I saw that kid from Huyton turn up for the first time. He's a great lad both on and off the pitch and I've nothing but praise for him." Former Liverpool captain Jamie Redknapp waxes lyrical about Steven Gerrard
La Liga: Pressure on Schuster and Real
Knocked out of the cup by Real Union of the Spanish third tier and beaten by Valladolid in the space of five days, Real Madrid have no option but to pick up three points against lowly Recreativo Huelva and impress in the process. Frontrunners Barcelona have no such worries, however, and have their sights trained on mid-table Getafe, who will pitch up at the Camp Nou hoping to prevent the Catalans from adding to their haul of 36 goals.
Sevilla will be looking to their Brazilian striker Fabiano to continue the form that saw him net a hat-trick for the Seleçao against Portugal in midweek. Currently lying fifth, the Andalusians receive a visit from Valencia on Saturday and have the incentive of leapfrogging above them should they win.
The question: Cameroonian hotshot Samuel Eto'o has scored 13 goals in 11 league outings this season. Can Getafe stop him from adding to that tally?
The big game: Sevilla-Valencia, Saturday 22.00 CET, Estadio Sanchez Pizjuan
The quote: "The match against Valencia is absolutely vital. It's the kind of game that should tell us if we have what it takes to fight for the top places. If we want to achieve something this season, we're going to have to work for it." Diego Capel, Sevilla forward
Bundesliga: Top two hit the road
Locked together at the top of the table, Bayer Leverkusen and TSG 1899 Hoffenheim resume their battle for supremacy with a brace of away games. Leaders on goal difference, Bayer seem to have the easier task in travelling to Arminia Bielefeld, who lie one place from the bottom, while revelations Hoffenheim take a trip to Cologne. With just one goal separating the two sides, the ongoing duel between the country's leading two goalscorers, Patrick Helmes of Bayer and TSG's Bosnian hitman Vedad Ibisevic, should prove absorbing.
Tucked behind in third, Bayern Munich welcome bottom-placed Energie Cottbus intent on putting last week's late collapse against Borussia Moenchengladbach behind them. And in the main attraction of Matchday 14, fifth plays seventh as fast-improving Hamburg do battle with Werder Bremen.
The question: Franck Ribery has been in impressive scoring form of late. Can the Frenchman extend his run of five goals in five games when Bayern go to Cottbus?
The big game: Hamburg-Werder Bremen, Sunday 23, 17.00 CET, HSH Nordbank Arena
The quote: "Sometimes we make life hard for ourselves and let matches slip. If we are going to get up with the leaders, we need to be more consistent and more intelligent." Hamburg and Germany midfielder Piotr Trochowski
Ligue 1: Bordeaux with no room for error
Outclassed by Olympique Lyon seven days ago, Bordeaux face another stiff examination with the visit of an upwardly mobile Stade Rennais. On the plus side Laurent Blanc's men have won their last three home games, a record they will need to extend if they are to maintain contact with the pacesetters.
After Marseille's disastrous 3-2 capitulation against Lorient last week, the Stade Velodrome faithful will be expecting some kind of reaction from their heroes when Lille come to town. Leaders Lyon journey to Paris to take on a PSG side that has been making the most of its goalscoring opportunities since Guillaume Hoarau and Ludovic Giuly were paired together up front. And down in the basement, rockbottom Valenciennes square off against Sochaux, the side just above them.
The question: PSG have not beaten Lyon at the Parc des Princes in four years. Will the Parisians buck the trend on Saturday?
The big game: Bordeaux-Stade Rennais, Saturday 19.00 CET, Stade Jacques Chaban-Delmas
The quote: "We are bottom of the league and going through a bad patch. The only thing that I'm focusing on, and my players too, is bouncing back and beating Sochaux." Antoine Kombouare, Valenciennes coach
The pick of the games in the rest of Europe sees fourth plays first in the Netherlands as AZ Alkmaar face Ajax. Victory for the Eredivisie leaders would take them five points clear of Louis van Gaal's charges.